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.   Staphylococcus caprae  is a coagulase-negative staphylococcus that has been reported in several cases as a human pathogen. However, it has rarely been reported as pathogen in native bone. Furthermore, the reported MIC levels noted in the literature for vancomycin were <2 µg ml −  1 making vancomycin a first line choice for infected patients.   Case presentation.  We report a case of  Staphylococcus caprae  causing osteomyelitis of the lumbar spine and bacteraemia and resulting in sepsis and ultimately the demise of a patient despite appropriate prolonged antibiotic therapy.   Conclusion.   Staphylococcus caprae  has been reported as a human pathogen since 1983 when it was discovered. We report a case involving native bone infection which is rare in the absence of mechanical hardware. Furthermore, this strain had an elevated MIC for vancomycin which has not been reported in the literature.

Staphylococcus caprae bacteraemia and native bone infection complicated by therapeutic failure and elevated MIC: a case report