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. Meningitis and endocarditis are common pathologies of  Streptococcus   suis  infections in pigs and humans.  S. suis  serotype 9 strains contribute substantially to health problems in European pig production, and immune prophylaxis against this serotype is very difficult.    Case presentation  . We report the clinical course and histopathological picture of a 10-week-old growing pig following experimental intravenous infection with  S. suis  serotype 9. The piglet showed rapid onset of severe clinical signs of meningitis 11 days post-intravenous challenge following prime-booster vaccination. Histopathological findings revealed a diffuse fibrinosuppurative leptomeningitis. Additionally, a polyphasic  endocarditis valvularis thromboticans  with numerous bacterial colonies was diagnosed. Bacteriological culture of the brain and the mitral valve confirmed association with the challenge strain. However, virulent serotype 2 and 9 strains were killed in the blood of this piglet  ex vivo  prior experimental infection.    Conclusion  . Endocarditis induced by  S. suis  infection might develop and persist despite the presence of high specific bactericidal activity in the blood. Severe leptomeningitis is a putative sequela of such an endocarditis.

Streptococcus suis serotype 9 endocarditis and subsequent severe meningitis in a growing pig despite specific bactericidal humoral immunity