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Achromobacter xylosoxidans is a non-fermentative aerobic Gram-negative bacillus, which most frequently causes nosocomial infections. Endocarditis from the pathogen has only rarely been reported and has a near-fatal outcome without surgical intervention.Case Presentation:We present a case of A. xylosoxidans endocarditis and septic arthritis in an infant affected by generalized arterial calcification of infancy. The patient was successfully treated with 6 weeks of intravenous colistin, meropenem and trimethoprim/sulfamethoxazole.Conclusion:This is the first reported case of colistin used to treat A. xylosoxidans endocarditis. We discuss the antibiotic challenges of treating multidrug-resistant A. xylosoxidans endocarditis in a patient who is not a surgical candidate.

Achromobacter xylosoxidans endocarditis and septic arthritis in an infant affected by generalized arterial calcification of infancy