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Severe bacterial infection is an unusual initial presentation of systemic lupus erythematosus (SLE).Case presentation:We describe two cases of severe encapsulated bacterial infection in women with previously undiagnosed SLE.Conclusion:Hypocomplementaemia associated with SLE is an important infection risk and should be considered in the evaluation of patients who present with unusual and severe infection with encapsulated bacteria.

jmm case reports

Severe infection with encapsulated bacteria as the initial presentation of systemic lupus erythematosus: two case reports and a review of the literature.