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Meticillin-resistant Staphylococcus aureus (MRSA) remains an important pathogen in the nosocomial setting and is being seen with increasing frequency within the community on a global basis (Fluit et al., 2001; Chambers, 2001). In recent years, there have been a considerable number of studies attempting to address the requirement for a rapid and economical method for determining strain relatedness in both local outbreak investigations and global epidemiological studies. Methods which span the entire genome, such as amplified fragment length polymorphism and PFGE, offer very high resolution and are used for distinguishing strains isolated over short periods of time (Melles et al., 2007), but do not lend themselves to the study of genetic relatedness or evolution. PFGE (the current ‘gold standard’) is criticized for being technically demanding and time-consuming, with difficulty in making interlaboratory comparisons (Sabat et al., 2006). Multilocus sequence typing (MLST), which assigns a strain to a sequence type (ST) based on the sequences of seven housekeeping genes, is often used for global studies (Robinson & Enright, 2004). However, the workload and expense associated with MLST mean that it is often limited to well-resourced facilities.

journal of medical microbiology/journal of medical microbiology

Detection of single nucleotide polymorphisms based on the multilocus sequence typing database of Staphylococcus aureus using locked nucleic acid oligonucleotides