English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Mycoplasma genitalium (MG) is a recognised sexually transmitted infection causing urethritis in men and women. There is a growing concern that M. genitalium could become an STI superbug due to its increasing resistance to first-line azithromycin (macrolides) and second-line moxifloxacin (fluoroquinolones) antibiotics. In Northern Ireland where routine testing for M. genitalium is extremely limited, the true knowledge of macrolide resistance is unknown therefore adherence to a syndromic approach for management of urethritis could facilitate the spread of resistance strains amongst sexual partners. The aim of this study was to obtain preliminary data on the prevalence and associated macrolide resistance of M. genitalium in male and female patients attending Genitourinary Medicine (GUM) clinic in Belfast using a commercially available assay. METHODS  A total of 1052 specimens were collected from 359 anonymised women and 693 anonymised men [figure 1].  200μl of each sample was obtained for the study after all routine testing was performed.  Samples were processed, extracted and tested against ResistancePlusTM MG assay (SpeeDx Pty Ltd, Sydney, Australia) in accordance to manufacturer’s instructions to simultaneously detect MG and macrolide resistance associated 23S rRNA mutations. RESULTS  41/1052 (3.9%) patients in the study tested positive for MG  MG positivity rates were as follows:8.13% (14/172) in rectal swabs, 4.18% (15/359) in vaginal / endocervical / genital swabs and 2.85% (12/421) in males urines. There were no positive penile or throat swabs.  Amongst all MG positives in the study, 24 (58.5%) had a 23s rRNA wild type gene and the remaining 17 (41.5%) had a 23S rRNA gene mutation known to confer macrolide resistance [see figure 2].  The rate of 23S rRNA mutations were highest among male urines (58.3%), followed by rectal swabs (50%) and then female swabs (20%) [figure 2]. 209

Macrolide-resistant Mycoplasma genitalium in male and female patients attending a Northern Irish Genitourinary Medicine Clinic