Open AccessEffects of Intestinal Micro-Organisms on Fluid and Electrolyte Transport in the Jejunum of the Rat
Author(s) -
Paul Thelen,
Valerie Burke,
Michael Gracey
Publication year - 1978
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-11-4-463
Subject(s) - microbiology and biotechnology , candida albicans , escherichia coli , staphylococcus epidermidis , jejunum , shigella , biology , lumen (anatomy) , enteritis , shigella sonnei , bacteria , chemistry , staphylococcus aureus , biochemistry , genetics , gene
Culture filtrates of micro-organisms isolated from the upper intestinal secretions of malnourished children and grown in pure culture were shown to impair the intestinal absorption of water and electrolytes in live rats. Decreased net movement out of the intestinal lumen, or actual secretion of water, sodium or potassium into the intestinal lumen, was found with culture filtrates of single isolates of Staphylococcus epidermidis, Escherichia coli 055, Escherichia coli B7A, Shigella sonnei, Klebsiella pneumoniae, Candida albicans and Candida tropicalis. These organisms have been found to contaminate upper intestinal secretions in malnourished children and it is suggested that the effects observed in these experiments might be relevant to the production of the diarrhoea that is a dominant clinical feature of childhood malnutrition.