Open AccessBlood coagulation, anti-coagulants and hæmolysis
Author(s) -
John W. Pickering,
F. Ë. Taylor
Publication year - 1924
Publication title -
proceedings of the royal society of london. series b, containing papers of a biological character
Language(s) - English
Resource type - Journals
eISSN - 2053-9185
pISSN - 0950-1193
DOI - 10.1098/rspb.1924.0040
Subject(s) - blood clotting , coagulation , heterologous , chemistry , lysis , clotting time , pharmacology , biochemistry , medicine , biomedical engineering , gene
Attention has recently been directed to the action of certain substances both in inhibiting the spontaneous clotting of blood and in affording protection against hæmolysis (Pickering and de Souza, 1). No systematic enquiry appears, however, to have been made into the possible influence of anticoagulants on the lysis of erythrocytes. We have found that most substances which restrain the clotting of blood are also anti-hæmolytic against heterologous sera, a specific hæmolysin, and cobra venom; also that certain agencies which restore the coagulability of blood after the influence of anti-coagulants will neutralise the anti-hæmolytic action of these substances.