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Calmette and Massoll have reported that immunisation of a calf with "bacillen-emulsion" has produced, not complemetn-fixation bodies, but an inhibitive effect which they designate as an "inhibiteur." Previous to this they had reported upon a serum, obtained by intravenous inoculation, which had an extremely active agglutinating property, and under certain conditions was capable of precipitating various solutions of tuberculin. The reaction of fixation was not, however, obtained with either the serum or the serum precipitate. Independently I had observed a somewhat analogous serum reaction (inhibitive reaction) in certain cases of pulmonary tuberculosis, and I first reported this at the meeting of the Canadian Medical Association, Toronto, June, 1910, subsequently publishing more extended investigations along these lines. These reactions have become an additional aid in the clinical estimation of the type of case. Emery records an observation which he regards as similar in character to that of Clamette and Massol. The variations in technique at present, however, prevent one from drawing any very close comparisons.

Factors in the interpretation of the inhibitive and fixation serum reactions in pulmonary tuberculosis