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Total parenteral nutrition (TPN), with the complete removal of enteral nutrition, results in marked changes in intestinal intraepithelial lymphocyte (IEL) function and phenotype. Previous work shows that TPN results in a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an important role in development of such TPN-associated IEL changes.

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Intestinal Specific Overexpression of Interleukin-7 Attenuates the Alternation of Intestinal Intraepithelial Lymphocytes After Total Parenteral Nutrition Administration