Open AccessThe Major Histocompatibility Complex Conserved Extended Haplotype 8.1 in AIDS-Related Non-Hodgkin Lymphoma
Author(s) -
Brahim Aı̈ssani,
Kisani M. Ogwaro,
Sadeep Shrestha,
Jianming Tang,
Elizabeth C. Breen,
Hui Lee Wong,
Lisa P. Jacobson,
Charles S. Rabkin,
Richard F. Ambinder,
Otoniel Martı́nez-Maza,
Richard A. Kaslow
Publication year - 2009
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181b017d5
Subject(s) - haplotype , linkage disequilibrium , single nucleotide polymorphism , odds ratio , lymphotoxin alpha , immunology , major histocompatibility complex , human leukocyte antigen , biology , genetics , medicine , allele , genotype , gene , tumor necrosis factor alpha , antigen , lymphotoxin
Two single nucleotide polymorphisms (SNPs) in adjacent genes, lymphotoxin alpha (LTA +252G, rs909253 A>G) and tumor necrosis factor (TNF -308A, rs1800629 G>A), form the G-A haplotype repeatedly associated with increased risk of non-Hodgkin lymphoma (NHL) in individuals uninfected with HIV-1. This association has been observed alone or in combination with human leukocyte antigens HLA-B*08 or HLA-DRB1*03 in the major histocompatibility complex (MHC). Which gene variant on this highly conserved extended haplotype (CEH 8.1) in whites most likely represents a true etiologic factor remains uncertain.