Open AccessAdjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis
Author(s) -
Joseph N Jarvis,
Graeme Meintjes,
Kevin Rebe,
Gertrude Ntombomzi Williams,
Tihana Bicanic,
Anthony Williams,
Charlotte Schutz,
LindaGail Bekker,
Robin Wood,
Thomas S. Harrison
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283536a93
Subject(s) - cryptococcus neoformans , amphotericin b , medicine , gastroenterology , cryptococcus , meningitis , confidence interval , fluconazole , mycosis , randomized controlled trial , mortality rate , immunology , cerebrospinal fluid , fungemia , cryptococcosis , surgery , biology , antifungal , microbiology and biotechnology , dermatology
Interferon-gamma (IFNγ) is of key importance in the immune response to Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and novel treatment strategies are needed. We performed a randomized controlled trial to determine whether addition of IFNγ to standard therapy increased the rate of clearance of cryptococcal infection in HIV-associated cryptococcal meningitis.