Open AccessTenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings
Author(s) -
John A. Moss,
Marc M. Baum,
Amanda M. Malone,
Sean Kennedy,
Etana Kopin,
Cali Nguyen,
Josh Gilman,
Irina Butkyavichene,
Robyn A. Willis,
Kathleen L. Vincent,
Massoud Motamedi,
Thomas J. Smith
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283509abb
Subject(s) - prodrug , pharmacokinetics , pharmacology , tenofovir , drug , in vivo , medicine , distribution (mathematics) , human immunodeficiency virus (hiv) , virology , biology , mathematical analysis , microbiology and biotechnology , mathematics
To compare the distribution of tenofovir in sheep vaginal lumen, tissue, and plasma following topical delivery of the antiretroviral drug from intravaginal rings, either as tenofovir or the disoproxil fumarate prodrug.