Open AccessDegradation and beyond
Author(s) -
Ismail Sergin,
Trent D. Evans,
Babak Razani
Publication year - 2015
Publication title -
current opinion in lipidology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.412
H-Index - 124
eISSN - 1473-6535
pISSN - 0957-9672
DOI - 10.1097/mol.0000000000000213
Subject(s) - tfeb , autophagy , microbiology and biotechnology , lysosome , organelle , biogenesis , macrophage , inflammasome , biology , transcription factor , inflammation , chemistry , immunology , biochemistry , apoptosis , gene , in vitro , enzyme
The ability of macrophage lysosomes to degrade both exogenous and internally derived cargo is paramount to handling the overabundance of lipid and cytotoxic material present in the atherosclerotic plaque. We will discuss recent insights in both classical and novel functions of the lysosomal apparatus, as it pertains to the pathophysiology of atherosclerosis.