Open AccessNhlh2
Author(s) -
Deborah J. Good,
Christopher A. Coyle,
Dana L. Fox
Publication year - 2008
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1097/jes.0b013e31818782dd
Subject(s) - basic helix loop helix , helix (gastropod) , transcription factor , biology , genetics , gene , dna binding protein , ecology , snail
In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.