Open AccessHospital-Based Surveillance for Rotavirus Gastroenteritis using Molecular Testing and Immunoassay During the 2011 Season in Botswana
Author(s) -
Henry Welch,
Andrew P. Steenhoff,
Unoda Chakalisa,
Tonya Arscott-Mills,
Loeto Mazhani,
Margaret Mokomane,
Sara Foster-Fabiano,
Kathleen E. Wirth,
Andrew Skinn,
Jeffrey M. Pernica,
Marek Śmieja,
David M. Goldfarb
Publication year - 2013
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/inf.0b013e3182847295
Subject(s) - rotavirus , acute gastroenteritis , case fatality rate , rotavirus vaccine , rotavirus gastroenteritis , medicine , rotavirus infections , immunoassay , virology , pediatrics , environmental health , immunology , virus , population , antibody
We describe rotavirus testing and clinical characteristics for children admitted with acute gastroenteritis during Botswana's 2011 rotavirus season. The rotavirus season extended from June to October with rotavirus-specific case fatality being 2.8%. Using molecular testing as reference, the immunochromatographic test had a sensitivity of 76.5% and specificity of 68.0%. Rotavirus vaccine may significantly reduce childhood morbidity and mortality in Botswana.