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Streptococcus pneumoniae causes a considerable amount of morbidity and mortality in children &lt;5. However, pneumococcal conjugate vaccines (PCVs) can prevent much of this burden. Until recently, PCVs were mostly available only in developed countries using a variety of dosing schedules. As more lower income countries make decisions to introduce PCV into their national immunization programs, an optimal schedule with which to administer PCV has become a key policy question.

Methods for a Systematic Review of Pneumococcal Conjugate Vaccine Dosing Schedules