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The standard treatment for locally advanced rectal cancer is preoperative chemoradiation and total mesorectal excision. After surgery, tumors are classified according to the depth of tumor invasion, nodal involvement, and tumor regression grade. However, these staging systems do not provide information about the distribution of residual cancer cells within the bowel wall.

Distribution of Residual Cancer Cells in the Bowel Wall After Neoadjuvant Chemoradiation in Patients With Rectal Cancer