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Other laboratory examinations revealed white blood cell To the Editor: Lipoprotein glomerulopathy (LPG) is an uncommon inherited renal disease characterized by count: 5.08 10/L, hemoglobin: 119 g/L, platelet count: 9 lipoprotein thrombi in the markedly dilated capillary lumina of affected glomeruli, high plasma concentrations of apolipoprotein E (apoE), and proteinuria. It mainly affects people of Japanese and Chinese origin, and approximately 117 cases have been reported to date. Several genetic studies have demonstrated thatAPOE gene mutations may lead to the development of LPG; however, conflicting published evidence has found that some patients with APOE variants were unaffected. Thus, further studies are needed to examine the role of APOE mutations in the pathogenesis of LPG. This study investigated a novel point mutation in the APOE gene in a family with one LPG patient and an asymptomatic carrier of the same APOE variant.

A novel apolipoprotein E mutation (p.Arg150Cys) in a Chinese patient with lipoprotein glomerulopathy