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without loss of opioid analgesia. Clin Pharmacol Ther 2010; 87:204–11 5. Dahan A, Aarts L, smith TW: Incidence, reversal, and prevention of opioid-induced respiratory depression. ANEsThEsIoLogy 2010; 112:226–38 6. Boom M, Niesters M, sarton E, Aarts L, smith TW, Dahan A: Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des 2012; 18:5994– 6004 7. okie s: A flood of opioids, a rising tide of deaths. N Engl J Med 2010; 363:1981–5 8. van Dorp E, yassen A, Dahan A: Naloxone treatment in opioid addiction: The risks and benefits. Expert opin Drug saf 2007; 6:125–32

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