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38. Ozek M, Uresin Y, Güngör M: Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice. Life Sci 2003; 72:1943–51 39. Toda N, Kishioka S, Hatano Y, Toda H: Modulation of opioid actions by nitric oxide signaling. Anesthesiology 2009; 110:166–81 40. Zhang J, Hoffert C, Vu HK, Groblewski T, Ahmad S, O’Donnell D: Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models. Eur J Neurosci 2003; 17:2750–4 41. Costa B, Colleoni M, Conti S, Trovato AE, Bianchi M, Sotgiu ML, Giagnoni G: Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain. Br J Pharmacol 2004; 141:4–8 42. Pol O, Murtra P, Caracuel L, Valverde O, Puig MM, Maldonado R: Expression of opioid receptors and c-fos in CB1 knockout mice exposed to neuropathic pain. Neuropharmacology 2006; 50:123–32 43. Megías J, Guillén MI, Clérigues V, Rojo AI, Cuadrado A, Castejón MA, Gomar F, Alcaraz MJ: Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. Biochem Pharmacol 2009; 77:1806–13 44. Watkins LR, Milligan ED, Maier SF: Glial activation: A driving force for pathological pain. Trends Neurosci 2001; 24:450–5 45. Mika J, Osikowicz M, Makuch W, Przewlocka B: Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 2007; 560:142–9 46. Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R: Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J Pharmacol Exp Ther 2006; 318:1315–22

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