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An acetylcholinesterase inhibitor donepezil currently is used to treat patients with Alzheimer disease. However, its direct effect on cerebral blood vessels has not been evaluated. The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response.

Cholinesterase Inhibitor Donepezil Dilates Cerebral Parenchymal Arterioles via the Activation of Neuronal Nitric Oxide Synthase