Open AccessPharmacokinetics and Pharmacodynamics of ASKP1240, a Fully Human Anti-CD40 Antibody, in Normal and Renal Transplanted Cynomolgus Monkeys
Author(s) -
Anlun Ma,
Hao Dun,
Lijun Song,
Yanxin Hu,
Lin Zeng,
Jing Bai,
Guangzhou Zhang,
Fumitaka Kinugasa,
Yasuhiro Miyao,
Shozo Sakuma,
Kazumichi Okimura,
Noriyuki Kasai,
Pierre Daloze,
Huifang Chen
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000440951.29757.bd
Subject(s) - pharmacokinetics , pharmacodynamics , medicine , pharmacology , receptor , antibody , kidney , urology , immunology
The purpose of this study was to evaluate the serum concentration of ASKP1240 (pharmacokinetics [PK]) and the CD40 occupancy of ASKP1240 (pharmacodynamics [PD]) in normal and renal transplanted Cynomolgus monkeys to clarify the PK/PD relationship.