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82 Comparing submuscular control biopsies, treatment type did not affect remodeling parameters (p=0.28). Regarding ADM biopsies, chemotherapy adversely impacted fibrous encapsulation relative to the untreated group (p=0.03), while chemotherapy with or without radiation adversely impacted Type I collagen area (p=0.02), cellular infi ltration (p<0.01), extracellular matrix deposition (p<0.04), scaffold degradation (p<0.01) and neovascularization (p<0.01). Radiation exacerbated the adverse impact of chemotherapy for cellular infi ltration, scaffold degradation, and neovascularization (p<0.01). Conversely, neoadjuvant chemotherapy caused a reduction in Type I (p=0.01) and III collagen (p=0.05), extracellular matrix deposition (p=0.03), and scaffold degradation (p=0.02) relative to the untreated group. Similarly, neoadjuvant radiation exacerbated the adverse effect of neoadjuvant chemotherapy for Type I collagen, ECM deposition, scaffold degradation, and neovascularization (p<0.01) (Table 1).

Acellular Dermal Matrix-Assisted Direct-to-Implant Breast Reconstruction and Capsular Contracture