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Fibromyalgia is associated with chronic widespread pain and insomnia. While sleep and pain are mutually influential, how the cortical thickness (CT) of pain-related brain regions influences that relationship (i.e., sleep architecture and evening/morning pain) is unknown. This study examined how the CT of two regions involved in pain processing - the anterior cingulate cortex (ACC) and insula - influenced the link between sleep architecture and evening vs next morning pain in women with fibromyalgia. Methods Thirty adults with fibromyalgia and insomnia (Mage=57.2, SD=13.1) completed overnight polysomnography and daily diaries (14 days) tracking sleep and pain [0–100 (most intense). Pain discrepancy (PD) is the average difference between nighttime and next morning pain (evening - morning). Participants underwent MRI, and FreeSurfer (v5.1.0) estimated CT. Multiple regressions examined CT’s influence on the sleep stage [%stage1, %stage2, %stage3, %rapid eye movement (REM)] and PD relationship (controlling for age and education). For significant CT moderation, significance of simple slopes at different CT levels were examined: high (1 SD above), average, and low (1 SD below). Results Right rostral ACC (rRACC) CT moderated the relationship between %stage2 (B=-1.41, SE=0.6, p=.03, R^2=0.14), %stage3 (B=2.10, SE=0.97, p=.04, R^2 =0.13), %REM (B=2.35, SE=1.12, p=.04, R^2=0.13) and PD. Greater %stage2 was associated with higher morning vs evening pain at high rRACC thickness (B=-0.67, SE=0.22, p=0.005). Greater %stage3 (B=0.97, SE=0.38, p=0.02) and %REM (B=0.92, SE=0.42, p=0.04) were associated with lower morning pain vs evening pain at high, but not average or low rRACC thickness. Left insula CT moderated the association between increased %stage3 and lower morning vs evening pain (B=2.91, SE=1.18, p=.02, R^2=0.34) at the average and high, but not low thickness levels (B=0.36, SE=0.17, p=0.05; B=1.41, SE=0.48, p=0.008 respectively). Conclusion High cortical thickness in the rRACC and average to high L-insula cortical thickness moderated the association between restorative sleep (%stage3, REM) and lower morning vs evening pain. Future studies examining the role of CT in pain-related brain regions on the association of restorative sleep with overnight pain processing are warranted. Support (if any) National Institute of Nursing Research (NR017168; PI: McCrae). Clinical trial NCT02001077 Sleep and Pain Interventions (SPIN2), University of Missouri (PI: McCrae).

383 Cortical thickness moderates association between sleep architecture and pain in adults with fibromyalgia