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Parasomnia episodes (PE) consist of abnormal behaviors during sleep. Using high-density EEG (HDEEG), we sought to quantify topographical differences in spectral power during PE in comparison to wake and sleep. Methods 17 adult subjects with a history of NREM sleep parasomnia underwent 256-electrode HDEEG recordings during recovery sleep after 25h of sleep deprivation. PE occurred either spontaneously or when triggered by a sound. Data preprocessing of PE, sleep and wake data included filtering at 1-25 Hz, careful epoch and channel selection, and adaptive mixture independent component analysis (AMICA). We compared topographies of delta (slow wave activity, or SWA) and theta power, alpha power, and beta/delta ratio (a marker of cortical arousal) between states using paired t-tests. All results were thresholded at p&amp;lt;0.05 corrected for multiple comparison using statistical non parametric mapping (SNPM). Results Clean data were obtained in 26 PE arising out of N2/N3 sleep in 11 subjects. During PE, delta and theta power were significantly higher than during wake but lower than during sleep in central regions (at uncorrected p&amp;lt;0.05 for sleep vs. PE delta power). Occipital alpha was lower during PE compared to wake, but higher during PE compared to sleep. Finally, beta/delta ratio values during PE were globally higher than in wake, but globally lower than during sleep. Conclusion The present results confirm and extend our previous findings of decreased SWA in central areas during baseline sleep in patients with NREM sleep PE. They suggest that higher cortical arousal in central regions may precipitate motor behaviors during PE. Alpha power and beta-delta ratio during PE were intermediate between sleep and wake, suggesting that PE are transitional states with an admixture of cortical arousal and cortical sleep. Future analyses will use source reconstruction to identify the cortical generators of observed scalp differences. Support This work was funded by the Swiss National Science Foundation and the Tiny Blue Dot foundation.

0808 High Density EEG Correlates Of NREM Sleep Parasomnia Episodes