English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

efficacy equivalent to that of an NSAID, so this effect is also under study in a randomized trial. Trials targeting IL-1 with a number of mAb inhibitors have been disappointing in terms of symptom control. Several recent studies have investigated the effects of anti-TNF therapies in OA, with variable results. Studies of erosive hand OA have resulted in reduced swollen joint counts and reduced structural deterioration in joints with baseline clinical synovitis, but generally there have been no sustained analgesic benefits, though often antiTNF therapy was given for short duration. Fewer studies have been conducted in knee OA, although a small number open-label study suggested good analgesic response. Through rational use of DMARDs we may determine the key inflammatory drivers of both pain and structural progression in OA. Disclosure statement: The author has declared no conflicts of interest.

I57. What is the Role of Type 17 Immune Responses in SPA Pathogenesis and Do they Define New Treatment Targets?