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This randomized, double-dummy, double-blind pilot study of acutely exacerbated low back pain was aimed to inform a definitive comparison between Doloteffin, a proprietary extract of Harpagophytum, and rofecoxib, a selective inhibitor of cyclo-oxygenase-2 (COX-2).

A randomized double-blind pilot study comparing Doloteffin(R) and Vioxx(R) in the treatment of low back pain