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Sodium-potassium-chloride cotransporter isoform 1 (NKCC1) is an active ions cotransporter and modulates cellular volume and migration. NKCC1 blockers can inhibit cancer cell growth.

Expression of Na+–K+-2Cl−cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma andEGFR-mutated adenocarcinoma patients