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Background Worldwide, breast cancer comprises 10.4% of all cancer incidences among women, making it the second most common type of non-skin cancer (after lung cancer) and the fifth most common cause of cancer death. In 2004, breast cancer caused 519,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths). Breast cancer is about 100 times more common in women than in men, although males tend to have poorer outcomes due to delays in diagnosis. Aim of the Work To clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Materials and Methods Our study was held as a retrospective cohort study to clarify clinical, pathological features and outcomes of the treatment modalities for Paget’s disease of the breast at Ain Shams University Hospitals. Results At Ain Shams university hospitals patients having pagetoid cells by biopsy and no mass radiologically underwent simple mastectomy and if pathology proved any malignancy in breast tissue axillary clearance was done and might be followed by radiotherapy. Conclusion Patients having pagetoid cells by biopsy and a mass radiologically which is invasive or insitu with microinvasion will undergo modified radical mastectomy and may be followed by radiotherapy. But if pagetoid cells and mass radiologically which is in situ simple mastectomy will be done.

Paget’s Disease of the Breast and Our Clinical Experience at Ain Shams University Hospitals