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Background Ukraine is among the five countries with the highest burden of multiple drug-resistance tuberculosis (MDR TB). MDR TB has found in 22 % new cases of TB and in 56 % of retreated cases in Ukraine (WHO, 2015), and the elderlies among TB-affected persons are near 23%. The aim was to study the resistance of Mycobacterium tuberculosis (Mtb) and outcomes of TB depending on Mtb strains’ genotypes among different age groups of TB patients. Methods In 2015–2016, 115 clinical cases of severe first diagnosed TB were studied. Identification of Mtb strains was made by using VNTR-genotyping by ETR A-E loci. Resistance of Mtb to drugs was done according to WHO recommendations. There was found out the large cluster of identical strains among Beijing`s family with VNTR-profile 42435 – 53 (46 %). All the cases were divided into 4 groups: group 1 – young adults, Mtb Beijing profile 42435, n = 29, group 2 – elderly adults, Mtb Beijing profile 42435, n = 24, group 3 – young adults, non-42435 profile, n = 29, group 4 – elderly adults, non-42435 profile, n = 33. The outcomes were analyzed after continuation phase of treatment. Results Beijing strains with VNTR profile 42435 were primary resistant in 37,7 %, and they become secondary resistant after at least 6 month treatment in 50,9 %. In cases of Beijing 42435-profile, the clinical courses of TB were very severe, with episodes of hemoptysis/pulmonary bleeding, the outcomes were unfavorable – treatment success was just in 35,7 % of cases, fail – 33,9 %, lost to follow up – 15,2 % and 15,2% of patients died, with no difference depend on the patient`s age, P < 0.05. Another Mtb strains were primary resistant in 30.6%, and they become secondary resistant after at least 6 month treatment in 32.3% (group 3 – 46.6%, group 4 – 18.8%, P < 0.01). The clinical courses of TB in cases of non-42435 VNTR profile were severe, but without episodes of hemoptysis/pulmonary bleeding, the outcomes were much more favorable – treatment success was in 58.1 % of cases (group 3 – 40%, group 4 – 75.1%, P < 0.05), fail – 22.5 %, lost to follow-up – 11.3% (group 3 – 20%, group 4 – 3.1%, P < 0,05). 8,1% of patients died, with no difference depend on the patient`s age, P < 0,05. Conclusion Beijing strains with VNTR-profile 42435 are spread very fast in Ukraine and compose the cluster of virulent primary resistant strains, with severe clinical course and worst outcomes. Disclosures O. S. Konstantynovska, Kharkiv Medical Academy of Postgraduate Education: Employee, Salary; P. I. Poteiko, Kharkiv Medical Academy of Postgraduate Education: Employee, Salary; M. M. Kochuieva, Kharkiv Medical Academy of Postgraduate Education: Member, Salary; I. I. Hrek, Kharkiv Medical Academy of Postgraduate Education: Employee, Salary; A. V. Rohozhin, Kharkiv Medical Academy of Postgraduate Education: Employee, Salary; O. S. Solodiankin, National Scientific Center â€œInstitute for Experimental and Clinical Veterinary Medicine: Employee, Salary

Resistance of Mycobacterium and Outcomes of Pulmonary Tuberculosis Depending on VNTR-Profile Among Different Age Groups of Patients in Ukraine