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We identified 50 cases of GAS bacteremia, 183 of GBS, and 277 of SDSE, respectively. The median age of the patients with SDSE bacteremia was 81 years, older than those with GAS and GBS bacteremia (61 and 71 years, respectively). Cardiovascular disease, malignancy, and diabetes mellitus were the most common underlying diseases of three groups. The cases without underlying diseases in GAS, GBS, and SDSE groups were 24.0%, 8.7% and 1.4%, respectively. The most common types of infections were skin/soft tissue infections (58.0%, 30.1 % and 63.9%, respectively), which were significantly lower in GBS group than GAS and SDSE (p<0.001 each). The cases of bacteremia without focus were found in 12.0%, 21.3% and 19.1%, respectively. Genital tract infections were significantly more frequent in GAS (8.0%, p=0.01) and GBS group (12.6%, p<0.001) than SDSE group (0.7%). Respiratory infections were significantly more frequent in GAS group (6.0%, p=0.03) than SDSE group (0.7%). Urinary tract infections were more frequent in GBS group (12.4%) rather than other groups. The cases of endocarditis were found in 4.0%, 6.6% and 5.1%, respectively. The 30-day mortality rates were similar in three groups. Highest rate of recurrent bacteremia was seen in SDSE group (11.2%). Conclusion:

open forum infectious diseases

Clinical characteristics of Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus dysgalactiae subsp. equisimilis bacteremia in adults: A 15-year retrospective study at a major teaching hospital in Okinawa, Japan