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Background Several studies have documented low knowledge, uptake and retention of pre-exposure prophylaxis (PrEP)—a biomedical intervention for HIV prevention—among young black MSM (YBMSM). Methods PrEP Chicago is a randomized controlled peer change intervention designed to promote uptake of PrEP among YBMSM. Participants were recruited using respondent-driven sampling and randomized to intervention or control conditions. Initial seeds for recruitment were selected based on their structural position in a previously described Facebook network. Intervention participants undergo a small group peer change agent workshop led by intervention staff. Booster phone calls are then conducted to participants approximately once per month. The primary focus of the intervention is to motivate participants to discuss PrEP within their social network. Controls attend a group sex-diary session and receive no boosters. After one year, participants cross over conditions. Results Intervention, n (%) Control, n (%) p value Age, mean (sd) 26.1 (4.2) 25.7 (4.3) 0.28 Education 0.034 Less than HS 11 (5.4) 19 (9.1) HS/GED 121 (59.0) 136 (65.4) More than HS 59 (28.8) 35 (16.8) Graduate/Professional 1 (0.5) 2 (1.0) Other/Don’t Know 13 (6.3) 16 (7.7) Employment 0.31 Employed 109 (52.2) 92 (43.0) Not Employed 81 (38.8) 9 (46.3) Disabled 6 (2.9) 7 (3.3) Don’t Know/Prefer not to answer 13 (6.2) 16 (7.5) Sexual Orientation 0.24 Gay 135 (64.6) 123 (57.5) Bisexual 46 (22.0) 62 (29.0) Other 28 (13.4) 29 (13.6) Ever Taken PrEP 0.79 No 202 (96.7) 208 (97.2) Yes 7 (3.3) 6 (2.8) HIV Status 0.62 Negative 78 (49.1) 71 (44.7) Positive 81 (50.9) 88 (55.3) A total of 423 (209 intervention, 214 control) participants were successfully recruited. Only 13 (3.1%) participants reported ever having taken PrEP while 169 (53.1%) participants tested positive for HIV at baseline. A difference in education was noted between intervention and control groups (P = 0.034). A majority of participants in both groups identified as gay or bisexual. Study retention was evaluated through completion of the first booster. Intervention participants successfully completed 63.7% of the first boosters. Conclusion PrEP Chicago is a network intervention aimed at increasing PrEP uptake among YBMSM and is showing promising study engagement. Additional examination of PrEP diffusion in the network is needed. Disclosures All authors: No reported disclosures.

open forum infectious diseases

Baseline Characteristics from PrEP Chicago: A Randomized Controlled Diffusion-Based Network Intervention for HIV Prevention Among Young Black Men Who Have Sex With Men