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Meningiomas are slow growing tumours of the meninges that affect brain and spinal cord. They account for a quarter of all primary brain tumours of the central nervous system. Accordingly to the WHO classification system, meningiomas are classified as grade I, atypical grade II and malignant grade III. Symptoms include headaches, focal neurological signs depending on localisation and seizures. The standard of treatment for these tumours is (radio)surgery. Nevertheless, it is estimated that one third of meningiomas cannot be operated or can be only partially resected, often leaving patients with significant morbidity. Current chemotherapies are not effective therefore it is a great medical need to find novel therapeutic options. We aimed to identify novel targets/biomarkers by analysing proteome and phosphoproteome of different grade meningiomas. Frozen tumour specimens as well as meningiomaderived primary tumour cells were analysed by mass spectrometry to decipher proteome and phosphoproteome. -Phosphoproteins were isolated by an additional purification step. Overall we analysed 22 meningiomas (8 grade I, 8 grade II and 6 grade III) for the proteome and 14 for the phosphoproteome (5 grade I, 5 grade II and 4 grade III). Comparative studies were performed to identify aberrantly overexpressed proteins and dysregulated pathways compared to healthy human meninges (N=3). Among the proteins found significantly upregulated in meningioma

P12.08 Proteome and phosphoproteome analysis identifies STAT1 as a novel target in different grade meningiomas