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1 Declaration  9 List of tables  10 Chapter one  10 Chapter two  10 Chapter eight  10 List of figures  11 Chapter one  11 Chapter two  12 Chapter three  12 Chapter four  13 Chapter five  14 Chapter six  18 Chapter seven  18 Abbreviations  20 Acknowledgements  28 Dissemination  29 Chapter 1: Introduction  30 1.1 LDHA  30 1.1.1 Lactate dehydrogenase (LDH)  30 1.1.2 The role of LDHA in cellular metabolism  32 1.1.3 Regulation of LDHA synthesis  34 1.1.4 Post-translational regulation of LDHA  38 1.1.5 The role of LDHA in the cell cycle  38 1.1.6 LDHA as a transcription factor  39 1.1.7 Other roles of LDHA  40 1.1.8 LDHA in the brain and cerebral spinal fluid  41 1.1.9 LDHA and tumour malignancy  44 1.1.10 The role of LDHA in tumour growth and survival  44 1.1.11 The role of LDHA in tumour migration and metastasis  47

MB-45LDHA AS A POTENTIAL THERAPEUTIC TARGET FOR MEDULLOBLASTOMA