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aspects versus safety and regulations. J Am Soc Nephrol 2002; 13 [Suppl 1]: S78–S83 20. Guth HJ, Gruska S, Kraatz G. On-line production of ultrapure substitution fluid reduces TNF-alpha and IL-6 release in patients on hemodiafiltration therapy. Int J Artif Organs 2003; 26: 181–187 21. Vaslaki LR, Berta K, Major L et al. On-line hemodiafiltration does not induce inflammatory response in end-stage renal disease patients: results from a multi-center cross-over study. Artif Organs 2005; 29: 406–412 22. Ward RA, Sadler JH. Microbiological quality requirements for dialysate: is it time for a change? Nephrol News Issues 2002; 11: 26, 28–29, 33–34, 36, 38, 40, 73

The use of IV iron in the treatment of anaemia of ESRD patients on maintenance haemodialysis: an historical and personal view