Vitamin D decreases NFκB activity by increasing IκBα levels | Zendy

M. Cohen | Zendy; Shraga Shany | Zendy; David Tobvin | Zendy; Cidio Chaimovitz | Zendy; Amos Douvdevani | Zendy

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Vitamin D decreases NFκB activity by increasing IκBα levels

Author(s) -

M. Cohen,

Shraga Shany,

David Tobvin,

Cidio Chaimovitz,

Amos Douvdevani

Publication year - 2006

Publication title -

nephrology dialysis transplantation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.654

H-Index - 168

eISSN - 1460-2385

pISSN - 0931-0509

DOI - 10.1093/ndt/gfi254

Subject(s) - medicine , tumor necrosis factor alpha , nf κb , transcription factor , nfkb1 , vitamin d and neurology , endocrinology , vitamin , inflammation , biochemistry , biology , gene

In a previous study we demonstrated the inhibitory effect of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) and its less calcaemic analog 1,24(OH)(2)D(2) on the production of tumour necrosis factor alpha (TNFalpha) by human peritoneal macrophages. The aim of the present study is to examine whether this vitamin D inhibition of TNFalpha is mediated by its major transcription factor, nuclear factor-kappaB (NFkappaB).

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