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Background and Aims Treatment of Minimal change disease (MCD) consists of high dose of steroids (HDS) for several weeks implying significant drug toxicity. On the other hand, renal relapses of steroid-sensitive MCD sometimes respond to lower doses of steroids. Method The objective of the study was to analyze weather low dose for steroids (LDS) is effective for treatment MCD relapses among frequently-relapsing steroid-sensitive patients. Since 2019, new relapses of steroid-sensitive patients with MCD within the Nephrology Department of Hospital Ramón y Cajal were treated with LDS. Cumulative dose of steroids, time to remission and time free of relapse were compared between relapse episodes treated with LDS and previous relapses among same patients treated with HDS. Results Twenty-six relapses among six steroid-sensitive MCD patients were analyzed. 15 relapses were treated with LDS and compared with 11 previous relapses among same patients treated with HDS. Mean dose of prednisone for initial treatment of the relapse was 0.89 ± 0.1 mg/kg in patients treated with HDS and 0.45 ± 0.1 mg/kg in patients treated with LDS. Mean cumulative dose of prednisone among patients treated with LDS and HSD were 1998.1 ± 1418 mg and 5611.7 ± 2326 mg, respectively. (p=0.001). Mean cumulative dose of prednisone adjusted by body weight among patients treated with LDS and HSD were 23.43 ± 14.27 mg/kg and 68.93 ± 27.05 mg/kg, respectively. (p=0.019). There was no difference in duration of treatment among HDS and LSD groups (163.45 ± 86.43 vs 138.80 ± 108.80, respectively; p = 0.525). All patients achieved complete remission after steroid therapy in both LSD and HSD groups. Mean time to remission was 18.7 days among HSD relapses and 18.4 days among the LSD relapses (p = 0.9). Time free of relapse after therapy among HDS and LDS treated relapses was 9.1 ± 5.3 months and 5.5 ± 3.5 months, respectively (p = 0.1). Conclusion Among steroid-sensitive MCD patients, relapse therapy with low dose of steroids (0.5 mg/kg) seems to be effective and allows minimization of steroid cumulative dose and drug toxicity.

P0399RELAPSE TREATMENT WITH LOW DOSE OF STEROIDS IN STEROID-SENSITIVE MINIMAL CHANGE DISEASE