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Background and Aims The Bai ethnic group is one of the officially recognized minorities in the People's Republic of China, with a total population of 1.93 million. More than 80% of the Bai ethnic group live in Dali Bai Autonomous Prefecture in Yunnan Province. Because of their dietary habit and chronic exposure to high altitude, hyperuricemia is not rare among the Bai ethnic group. Hyperuricemia is not only related to the presence of hypertension, obesity and dyslipidemia, but also increases the risks of stroke, heart disease and chronic kidney disease. But the prevalence of hyperuricemia in the Bai ethnic group remains unclear. Method We collected the demographic information as well as laboratory test results of 1393 Bai ethnic people undergoing medical examination during Jan 2019 to Dec 2019 in the People's Hospital of Jianchuan County, Yunnan Province (average altitude 2300m). Written informed consent was obtained from all the participants. Hyperuricemia is defined as serum uric acid level superior to 360 μmol/L for female and 420 μmol/L for male. We investigated the prevalence of hyperuricemia and its risk factors in the Bai ethnic group in southwestern China. Results Of the 1393 participants enrolled in the study, the prevalence of hyperuricemia was 24.8%, and the prevalence was significantly higher in male gender (33.2% in men vs. 11.0% in women, P&amp;lt;0.001). The prevalence of hyperuricemia increased from 19.2% among participants aged 30-40 years to 30.1% among participants aged 50 years and older (Fig 1). Also, the prevalence of hyperuricemia elevated from 17.2% among participants with normal body mass index (BMI) to 35.5% among those who were overweighed or obese (Fig 2). Interestingly, we found a positive correlation between hemoglobin level and serum uric acid (β=2.19, P&amp;lt;0.01). Logistic regression analysis revealed main risk factors for hyperuricemia in the Bai ethnic group included age, sex, BMI, systolic blood pressure (SBP) and hemoglobin level. Conclusion Hyperuricemia is common in the Bai ethnic group. Its prevalence differs in different sex, age and BMI groups. Furthermore, polycythemia secondary to chronic exposure to high altitude may also contribute to the hyperuricemia.

P0177PREVALENCE AND RISK FACTORS OF HYPERURICEMIA IN THE BAI ETHNIC GROUP IN SOUTHWESTERN CHINA