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PURPOSE AND DESIGN OF STUDY: Asymmetric-induced changes of the renogram under angiotensin-converting enzyme inhibition (ACE-i), i.e. lateralization, is probably the most distinctive finding for the detection of haemodynamically significant renal artery stenosis (RAS) in compensated kidney, since bilateral and symmetric patterns are non-specific. In the Consensus statement of diagnostic criteria of renovascular hypertension with captopril renography (Am J Hypertens 1991; 4: 749-755S) ACE-i-induced asymmetry of renograms for the left and right kidney was viewed as vitally important. However, detection of change in split function is a reliable parameter only when using a glomerular tracer, i.e. 99mTc-DTPA. No indication regarding a more widely used tubular tracer such as 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) has been given.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

Captopril-enhanced scintigraphy using the method of the expected renogram: improved detection of patients with renin-dependent hypertension due to functionally significant renal artery stenosis