Open AccessStructural transition of d(G4T4G4) from antiparallel to parallel G-quartet induced by divalent cations
Author(s) -
Daisuke Miyoshi,
Atsushi Nakao,
Norihiko Sugimoto
Publication year - 2001
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/1.1.259
Subject(s) - divalent , antiparallel (mathematics) , chemistry , crystallography , divalent metal , stereochemistry , inorganic chemistry , physics , organic chemistry , quantum mechanics , magnetic field , metal
We obtained thermodynamic parameters of an antiparallel G-quartet formation of d(G4T4G4) with 1 mM divalent cation (Mg2+, Ca2+, Mn2+, Co2+, or Zn2+). In addition, we also found that a higher concentration of a divalent cation induced a transition from an antiparallel to a parallel G-quartet structure. These results indicate that the divalent cations are a good tool for regulating the G-quartet structures and their stability.
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