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Cystadenoma is a rare benign salivary gland neoplasm characterized by a predominantly multicystic growth pattern. The parotid gland is involved in about 45–50% of cystadenoma cases, with the minor glands of the lip and buccal mucosa being the next most common sites. The tongue is rarely involved; only one congenital case is reported in the literature. Here, we report a 63-year-old man who was referred to our hospital for a nodule on the right edge of his tongue that developed into an elastic soft mass, 4 mm in diameter. It was clinically diagnosed as a benign tumour and removed under local anaesthesia. Microscopically, the lesion was composed of multiple cysts of various sizes and shapes, with or without papillary intraluminal short projections. It was diagnosed as cystadenoma. The postoperative course was uneventful, and we found no evidence of recurrence at the postoperative 14-year follow-up.

Cystadenoma of the tongue: report of a case with long-term follow-up