Open AccessBreast Cancer Risk After Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers: Revisiting the Evidence for Risk Reduction
Author(s) -
Bernadette A. M. Heemskerk-Gerritsen,
Caroline Seynaeve,
Christie J. van Asperen,
Margreet G.E.M. Ausems,
J. Margriet Collée,
Helena C. van Doorn,
Encarna B. Gómez-García,
C. Marleen Kets,
Flora E. van Leeuwen,
Hanne E.J. Meijers-Heijboer,
Marian J.E. Mourits,
Theo A.M. van Os,
Hans F. A. Vasen,
Senno Verhoef,
Matti A. Rookus,
Maartje J. Hooning
Publication year - 2015
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djv033
Subject(s) - hazard ratio , medicine , confidence interval , breast cancer , odds ratio , ovarian cancer , oncology , logistic regression , proportional hazards model , gynecology , cohort , cancer , obstetrics
Previous studies have reported a breast cancer (BC) risk reduction of approximately 50% after risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers, but may have been subject to several types of bias. The purpose of this nationwide cohort study was to assess potential bias in the estimated BC risk reduction after RRSO.