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Lasofoxifene is a SERM, or selective estrogen receptor modulator, that, like tamoxifen, blocks the effects of estrogen in breast tissue. Another SERM, raloxifene, has been shown to reduce breast cancer risk. In the Postmenopausal Evaluation and Risk-Reduction with Lasofoxifene (PEARL) trial, a double-blind, placebo-controlled, randomized trial, 8556 postmenopausal women with low bone density and normal mammograms were randomly assigned to two doses of lasofoxifene-either .25 or .50 milligrams of it per day, or placebo.

Lasofoxifene Reduces Breast Cancer Risk in Postmenopausal Osteoporotic Women