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The 13-nation Interphone study was supposed to establish, once and for all, whether a link between cell phone use and brain tumors exists. But after 10 years and more than $25 million, the only clear message to emerge was that more research was needed. The study, which the International Agency for Research on Cancer sponsored and the International Journal of Epidemiology reported last month, spawned confusing press reports. The Evening Times (Glasgow) trumpeted, " Phones not linked to cancer, " while the Sunday Times (London) declared, " Heavy mobile users risk cancer " — and other headline writers tried to take positions between the extremes. If the lay press didn't know what to make of the results, the Interphone researchers also seemed to have trouble agreeing on what the study showed. of the Karolinska Institute in Stockholm, an Interphone study group member, said in a press release, " The use of mobile phones for over 10 years shows no increased risk of brain tumors. " But principal investigator Elisabeth Cardis, Ph.D. , of the Centre for Research in Environmental Epidemiology in Barcelona, told Microwave News , " To me, there's certainly smoke here. Overall, my opinion is that the results show a real effect. " In an interview with JNCI 2 weeks later, Cardis was more careful: " We have not demonstrated an increased risk of brain cancer, " she said. " But I think it's important to point out that. .. we also have not demonstrated that there's no risk. " Range of Interpretation Cardis acknowledged " a range of interpretation among the investigators about whether there is an effect [of cell phone use on the risk of brain tumors] or whether the results are related to bias. .. . Some investigators think there is probably no risk, and the increased odds ratios are just artifacts. Others, on the contrary , think many of the odds ratios may be underestimated. All of these interpretations are legitimate. " Jack Siemiatycki, Ph.D., of the University of Montreal, who directed one of the Canadian Interphone centers, concluded, " For the great majority of users — about 90% — the message is rather encouraging. There was absolutely no evidence of any risk. There is some doubt in the top 10% of usage, which corresponds to more than 100,000 minutes of cell phone use. If a " We have not demonstrated an increased risk …

One Conclusion Emerges From Interphone Study: Controversy Will Continue