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In the current study, Liang Cheng, M.D., of the Indiana University School of Medicine in Indianapolis, and colleagues examined 70 lung cancer tumors from 23 female and seven male patients to determine whether multiple tumors from an individual patient shared a common genetic pattern. The investigators analyzed the tumors for chromosome loss at six loci previously associated with lung cancer and for mutations in the TP53 gene. They also analyzed the X-chromosome inactivation pattern in tumors from female patients.

Multifocal Lung Cancers Appear to Originate from Single Cancer Clone