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To reduce severe acute and late toxicities without compromising organ preservation survival in patients with locoregionally advanced head and neck squamous cell carcinoma, we performed three-drug induction methotrexate-cisplatin-fluorouracil with weekly cisplatin-fluorouracil concurrent chemoradiation.

japanese journal of clinical oncology

Promising Long-term Results with Attenuated Adverse Effects by Methotrexate-containing Sequential Chemoradiation Therapy in Locally Advanced Head and Neck Squamous Cell Carcinoma