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We conducted a Phase I study to evaluate the safety and efficacy of a combination of S-1 with semi-weekly low-dose cisplatin in patients with unresectable/recurrent gastric cancer to determine the recommended dose (RD) for a subsequent Phase II study.

japanese journal of clinical oncology

A Phase I Study of Combination Therapy of the Oral Fluorinated Pyrimidine Compound S-1 with Low-dose Cisplatin Twice-a-week Administration (JFMC27-9902 Step2) in Patients with Advanced Gastric Cancer Using a Continual Reassessment Method