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Objective Comparing the characteristics of end-of-dose failure patients and non-end-of-dose failure patients in the Chinese population and exploring the factors that may affect the occurrence of end-of-dose failure in cancer pain patients. Methods The outpatient with cancer pain from 2016 to 2019 were collected through hospital information system, and patients were included who met the following criteria: patients with the average numerical rating scale  ≥4 points within 3 days after taking the oxycodone sustained-release preparation, titrated to an effective therapeutic dose suitable for patients, had at least two clinical visits information of the patient with a minimum of ≥3 days between visits, the average numerical rating scale of the next visit after the treatment of occasional pain is ≥4, and were divided into end-of-dose failure group and non-end-of-dose failure group. Results Age (P &amp;lt; 0.05, odds ratio 0.933), diagnosis of nasopharyngeal carcinoma (P &amp;lt; 0.05, odds ratio 0.009), pain site is the head and neck (P &amp;lt; 0.05, odds ratio 0.005) and the abdomen (P &amp;lt; 0.01, odds ratio 0.021), and the metastatic site is the liver (P &amp;lt; 0.05, odds ratio 0.001) are related to the occurrence of end-of-dose failure. Conclusions Younger patients are more likely to develop end-of-dose failure. Patients diagnosed with nasopharyngeal cancer, with pain in the head and neck and abdomen, and with liver metastases have a lower incidence of end-of-dose failure.

japanese journal of clinical oncology

Influencing factors of end-of-dose failure in patients with cancer pain after oral oxycodone sustained-release tablets: a retrospective, case–control study