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To evaluate the antitumor activity in patients with T3b, T4 or metastatic urothelial carcinoma treated with MEC or M-VAC chemotherapy, by performing a multi-center randomized prospective study.

japanese journal of clinical oncology

Efficacy of Dose-intensified MEC (Methotrexate, Epirubicin and Cisplatin) Chemotherapy for Advanced Urothelial Carcinoma: a Prospective Randomized Trial Comparing MEC and M-VAC (Methotrexate, Vinblastine, Doxorubicin and Cisplatin)